​The C5ISR Center organization is structured into six directorates which are located at Aberdeen Proving Ground, Maryland, Fort Belvoir, Virginia, Joint Base McGuire-Dix-Lakehurst, New Jersey, Fort Sill, Oklahoma, and Fort Huachuca, Arizona.

The C5ISR Center is part of the U.S. Army Combat Capabilities Development Command (DEVCOM), which develops technology and engineering solutions for America's Soldiers.

DEVCOM is a major subordinate command of the U.S. Army Futures Command (AFC).  AFC describes itself as being "on a quest to modernize the way the Army does business by creating a space of endless possibilities to explore, develop, and test new methods, organizations, and technologies. Above all else, the command wants to ensure Soldiers have what they need, before they need it, to protect tomorrow… today.